Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine
نویسندگان
چکیده
منابع مشابه
Formulation and evaluation of monolithic matrix polymer films for transdermal delivery of nitrendipine.
The objective of the present work was to develop a suitable transdermal drug delivery system for nitrendipine. Polymeric films of nitrendipine were prepared by the film casting technique (glass ring) on mercury substrate. They were evaluated for physicochemical parameters, in vitro release and ex vivo permeation (heat separated human epidermis). Release of the drug from the films followed anoma...
متن کاملFormulation and Evaluation of Nitrendipine Buccal Films
A mucoadhesive drug delivery system for systemic delivery of nitrendipine, a calcium channel blocker through buccal route was formulated. Mucoadhesive polymers like hydroxypropylmethylcellulose K-100, hydroxypropylcellulose, sodium carboxymethylcellulose, sodium alginate, polyvinyl alcohol, polyvinyl pyrrolidone K-30 and carbopol-934P were used for film fabrication. The films were evaluated for...
متن کاملformulation and evaluation of liposomes for transdermal delivery of celecoxib
materials and methods liposomes were prepared by thin film method using soya lecithin and cholesterol. physicochemical characteristics of the liposomes such as, particle size, drug encapsulation efficiency were determined. also, drug release and in vitro skin permeability through rat skin were evaluated using franz diffusion cells. results the results showed that the maximum drug encapsulation ...
متن کاملFormulation and Evaluation of Liposomes for Transdermal Delivery of Celecoxib
BACKGROUND Celecoxib is a selective cyclo-oxygenase-2 inhibitor recommended orally to treat arthritis and osteoarthritis. It is a highly lipophilic, poorly soluble drug with oral bioavailability of around 40%. Long term oral administration of celecoxib causes serious gastrointestinal side effects. OBJECTIVES The current study aimed to assess the skin permeation of celecoxib by a transdermally...
متن کاملFormulation and Evaluation of Transdermal Films of Salbutamol Sulphate
Transdermal drug delivery systems of salbutamol sulphate using eudragit RL100 and PVP were developed by solvent casting technique employing mercury as a substrate. Propylene glycol was used as a plasticizer. The prepared films exhibited satisfactory physico-chemical characteristics. In vitro permeation profiles across the guinea-pig dorsal skin using K-C diffusion cell are reported. Incorporati...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Pharmaceutica
سال: 2009
ISSN: 1846-9558,1330-0075
DOI: 10.2478/v10007-009-0032-9